Looking for a comforting and hearty meal that combines two favorites? Try this Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup! This dish layers creamy macaroni and cheese with savory meatloaf, creating a delicious casserole that’s perfect for family dinners or gatherings. With its rich flavors and satisfying textures, this casserole is sure to become a go-to recipe for any occasion.

Jump to:
- Why You’ll Love This Recipe
- Tools and Preparation
- Essential Tools and Equipment
- Importance of Each Tool
- Ingredients
- For the Meatloaf Layer
- For the Mac and Cheese Layer
- For Garnish
- How to Make Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
- Step 1: Preheat the Oven
- Step 2: Prepare Meatloaf
- Step 3: Bake Meatloaf
- Step 4: Cook Macaroni
- Step 5: Make Cheese Sauce
- Step 6: Combine
- Step 7: Bake Again
- How to Serve Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
- Pair with a Fresh Salad
- Add Some Crunch
- Offer Extra Toppings
- How to Perfect Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
- Best Side Dishes for Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
- Common Mistakes to Avoid
- Refrigerator Storage
- Freezing Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
- Reheating Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
- Frequently Asked Questions
- What is Mac and Cheese Meatloaf Casserole?
- Can I use turkey instead of beef for the meatloaf?
- How do I customize my Mac and Cheese Meatloaf Casserole?
- Is this casserole suitable for meal prep?
- Final Thoughts
- 📖 Recipe Card
Why You’ll Love This Recipe
- Delicious Flavor Combination: The pairing of cheesy macaroni and savory meatloaf creates an unforgettable taste experience.
- Easy to Prepare: This recipe is straightforward, making it perfect for both novice cooks and seasoned chefs.
- Perfect for Meal Prep: Make it ahead of time and reheat for quick weeknight dinners or lunches.
- Family-Friendly: Kids love the cheesy goodness, while adults appreciate the heartiness of meatloaf.
- Versatile Options: Customize with your favorite seasonings or add veggies for a personal touch.
Tools and Preparation
Before diving into the cooking process, gather your tools. Having everything ready will make your experience smoother.
Essential Tools and Equipment
- Baking dish (9×13 inches)
- Mixing bowl
- Saucepan
- Whisk
- Cooking pot
Importance of Each Tool
- Baking dish: Essential for holding all layers together while baking evenly.
- Mixing bowl: Perfect for combining ingredients without mess.
- Saucepan: Ideal for making the creamy cheese sauce that ties the dish together.
- Whisk: Helps achieve a smooth sauce by mixing ingredients thoroughly.
Ingredients
For the Meatloaf Layer
- 1 lb ground beef
- 1/2 cup onion, diced
- 1/2 cup breadcrumbs
- 1 large egg
- 1/4 cup milk
- 1 tsp salt
- 1/2 tsp pepper
For the Mac and Cheese Layer
- 2 cups macaroni, uncooked
- 2 cups cheddar cheese, shredded
- 2 tbsp butter
- 2 tbsp flour
- 2 cups milk
- 1/2 tsp salt
- 1/4 tsp pepper
- 1/2 tsp paprika
- 1/2 tsp dry mustard
For Garnish
- 2 tablespoons fresh parsley, finely chopped

How to Make Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
Step 1: Preheat the Oven
Preheat your oven to 350°F (175°C). This ensures even cooking throughout your casserole.
Step 2: Prepare Meatloaf
In a mixing bowl, combine:
1. Ground beef
2. Diced onion
3. Breadcrumbs
4. Egg
5. Milk
6. Salt
7. Pepper
Mix well until combined, then press the mixture into the bottom of a greased 9×13-inch baking dish.
Step 3: Bake Meatloaf
Bake the meatloaf in the preheated oven for 20 minutes. This step starts cooking the meatloaf so it can hold its shape when layered with macaroni.
Step 4: Cook Macaroni
While the meatloaf is baking:
1. Cook macaroni according to package directions.
2. Drain and set aside once cooked.
Step 5: Make Cheese Sauce
In a saucepan over medium heat:
1. Melt butter.
2. Stir in flour and cook for about 1 minute.
3. Gradually whisk in milk until thickened.
4. Stir in salt, pepper, paprika, dry mustard, and 1 1/2 cups of cheese until melted and smooth.
Step 6: Combine
Stir cooked macaroni into the cheese sauce until fully coated. Pour this mixture over the partially cooked meatloaf. Sprinkle remaining cheese on top to create a delicious crust.
Step 7: Bake Again
Return to oven and bake for an additional 25 minutes or until cheese is melted and bubbly on top.
Enjoy your Mac and Cheese Meatloaf Casserole, perfect for family dinners or special occasions!
How to Serve Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
Serving Mac and Cheese Meatloaf Casserole is all about enhancing its comforting flavors while keeping it simple. This dish is perfect for family dinners or gatherings, and you can elevate the experience with a few tasty accompaniments.
Pair with a Fresh Salad
- Garden Salad: A light garden salad with mixed greens, cherry tomatoes, and cucumbers adds freshness.
- Caesar Salad: Creamy Caesar dressing complements the rich flavors of the casserole.
Add Some Crunch
- Garlic Bread: Crispy garlic bread is a classic pairing that can soak up extra cheese sauce.
- Cornbread: Sweet cornbread provides a delightful contrast to the savory meatloaf.
Offer Extra Toppings
- Chopped Green Onions: Sprinkle fresh green onions on top for a pop of color and flavor.
- Sour Cream: A dollop of sour cream adds creaminess and balances the dish’s richness.
How to Perfect Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
Making the ultimate Mac and Cheese Meatloaf Casserole is all about attention to detail. Here are some tips to ensure your dish turns out perfectly every time.
- Bold seasoning: Don’t be shy with salt and pepper; they enhance all the flavors in your casserole.
- Use quality cheese: Opt for sharp cheddar for a richer taste that elevates your cheese sauce.
- Don’t overcook pasta: Cook macaroni al dente since it will continue cooking in the oven.
- Layer wisely: Ensure even distribution when layering macaroni and cheese over meatloaf for balanced bites.

Best Side Dishes for Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
Pairing side dishes with your Mac and Cheese Meatloaf Casserole can make your meal even more enjoyable. Here are some great options to consider.
- Steamed Broccoli: Lightly steamed broccoli provides a nutritious crunch alongside the creamy casserole.
- Roasted Brussels Sprouts: Roasting brings out their natural sweetness, which pairs well with savory dishes.
- Coleslaw: A tangy coleslaw adds a refreshing contrast to the richness of the casserole.
- Baked Beans: Sweet baked beans offer a hearty complement that enhances the comfort food experience.
- Mashed Potatoes: Creamy mashed potatoes create an indulgent meal when served alongside this casserole.
- Fruit Salad: A fruit salad introduces bright flavors that can cleanse the palate after each rich bite.
Common Mistakes to Avoid
Making Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup can be simple, but avoiding common mistakes will ensure the best results.
- Skipping the Preheat: Always preheat your oven before baking. This helps cook the dish evenly from the start.
- Overmixing the Meatloaf: Mixing too much can make the meatloaf tough. Mix just until combined for a tender texture.
- Not Salting the Water: Failing to salt the pasta water means bland macaroni. Salt enhances flavor, so don’t skip this step!
- Using Cold Ingredients: Ensure eggs and milk are at room temperature. Cold ingredients can affect cooking time and texture.
- Ignoring Cheese Quality: Using low-quality cheese may lead to clumpy sauce. Choose good quality cheese for creaminess and flavor.
Refrigerator Storage
- Store in an airtight container.
- It lasts up to 3-4 days in the refrigerator.
Freezing Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
- Use a freezer-safe container or wrap tightly in plastic wrap.
- You can freeze it for up to 3 months.
Reheating Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
- Oven: Preheat to 350°F (175°C). Cover with foil and bake for about 25 minutes until heated through.
- Microwave: Place in a microwave-safe dish, cover, and heat in 1-minute intervals until warm.
- Stovetop: Heat on medium-low heat, stirring occasionally until warmed through; add a splash of milk if needed.

Frequently Asked Questions
What is Mac and Cheese Meatloaf Casserole?
Mac and Cheese Meatloaf Casserole is a hearty dish that combines layers of creamy macaroni and cheese with savory meatloaf, creating a comforting meal.
Can I use turkey instead of beef for the meatloaf?
Yes, you can substitute ground turkey for ground beef. This will result in a lighter version of the casserole while maintaining its delicious flavor.
How do I customize my Mac and Cheese Meatloaf Casserole?
Feel free to add vegetables like spinach or bell peppers or mix different cheeses for unique flavors. You can also adjust spices to your taste.
Is this casserole suitable for meal prep?
Absolutely! It’s perfect for meal prep as it stores well in the fridge or freezer, making it easy to enjoy throughout the week.
Final Thoughts
This Mac and Cheese Meatloaf Casserole is not only comforting but also versatile enough to suit various tastes. Whether you’re feeding a family or prepping for busy nights, this dish offers satisfying flavors. Don’t hesitate to customize it with your favorite ingredients! Try it today for a delightful meal everyone will love.
Did You Enjoy Making This Recipe? Please rate this recipe with ⭐⭐⭐⭐⭐ or leave a comment.
📖 Recipe Card
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Mac and Cheese Meatloaf Casserole
- Total Time: 1 hour 5 minutes
- Yield: Serves approximately eight people 1x
Description
Looking for the perfect comfort food that combines two classics? Try Mac and Cheese Meatloaf Casserole! This delicious dish layers creamy macaroni and cheese with a savory meatloaf, creating a hearty casserole that’s ideal for family dinners or gatherings. With its rich flavors and satisfying textures, it’s bound to become a favorite in your household.
Ingredients
- 1 lb ground beef
- 1/2 cup diced onion
- 1/2 cup breadcrumbs
- 1 large egg
- 2 cups macaroni, uncooked
- 2 cups shredded cheddar cheese
- 4 cups milk (divided)
- 2 tbsp butter
- Various seasonings (salt, pepper, paprika, dry mustard)
Instructions
- Preheat oven to 350°F (175°C).
- In a mixing bowl, combine ground beef, onion, breadcrumbs, egg, milk, salt, and pepper. Press into a greased 9×13-inch baking dish.
- Bake the meatloaf for 20 minutes.
- Cook the macaroni according to package instructions; drain.
- In a saucepan, melt butter over medium heat. Stir in flour; gradually whisk in 2 cups of milk until thickened. Add seasonings and 1½ cups cheese until melted.
- Mix cooked macaroni into the cheese sauce. Pour over the meatloaf; sprinkle remaining cheese on top.
- Bake for an additional 25 minutes until bubbly.
- Prep Time: 20 minutes
- Cook Time: 45 minutes
- Category: Main
- Method: Baking
- Cuisine: American
Nutrition
- Serving Size: 1 slice (approximately 300g)
- Calories: 450
- Sugar: 5g
- Sodium: 850mg
- Fat: 24g
- Saturated Fat: 10g
- Unsaturated Fat: 12g
- Trans Fat: 0g
- Carbohydrates: 34g
- Fiber: 2g
- Protein: 28g
- Cholesterol: 90mg





